I hope if I can use a material ulternative to synthetic bone to the bony defact after syrgery in dental practice. ( because synthetic bone very expansive to the patients, )
Chitosan has interesting properties which make it ideal for many biomedical and pharmaceutical applications; however, the mechanical properties of the resulting scaffolds are poor. That is why for the application of chitosan in bone and cartilage engineering, composite implants made of chitosan with certain bioactive ceramics and glasses have been developed for improving these properties. Silk fibroin/chitosan implants have been developed as well for the same purpose.
Examples:
http://www.sciencedirect.com/science/article/pii/S0142961211014980
http://www.sciencedirect.com/science/article/pii/S1385894710000963
http://iopscience.iop.org/article/10.1088/1748-6041/7/5/054104/meta
Regards,
In our experience can be used as a vehicle of other biomaterials but by itself is only antiseptic and healing
It can be used for copolymer. Synthetic bone is best if you use HAp from other sources. Try using bones from fish.
In our experience can be used as a vehicle of other biomaterials but by itself is only antiseptic and healing
Composite CTS-based materials have been found to have a predominant role in bone tissue engineering in recent years. The combination of biocompatible polymers and bioresorbable ceramic materials can mimic the natural function of bone. CTS with HAp composites are found to be potential bone implant materials with good osteoconductive, osteoinductive and osteogenic properties. The structural, mechanical, chemical interaction and in vitro study of CTS, HAp and CNT have been carried out for bone tissue engineering. Although many CTS/HAp composite materials have been developed, problems persist with their mechanical properties. Hence, much research is in progress to address the gap in the development of mechanical properties. Much research work is still needed to address the cytotoxicity of CNTs. Though challenges still exist, the addition of CNT to improve the mechanical properties of CTS and ceramic (HAp) composite would surely support and stimulate the function of natural bone. The development of research on the efficacy of CTS composite will open great possibilities for future bone tissue engineering.