Hi,
The Current Medicinal Chemistry journal has recently published an special issue on this topic. Maybe it will be useful to you:
http://www.benthamdirect.org/pages/1039/128903/current-medicinal-chemistry/vol-19/issue-5.htm
http://www.benthamdirect.org/pages/1039/128903/current-medicinal-chemistry/vol-19/issue-5.htm
I am not an expert in cancer, but I know professor Arcangeli Annarosa from U of Florence has done a lot electophysiology and cancer cells. See the manuscript published in 'Recent Pat Anticancer Drug Discov. 2012 May 8': Potassium Channels: Novel Emerging Biomarkers and Targets for Therapy in Cancer.
D'Amico M, Gasparoli L, Arcangeli A.
Also you can take a look to the work of Luis Ángel Pardo (Max Planck Institute of Experimental Medicine, Göttingen) about ion channels and cancer. Here you have links to some of his reviews:
http://www.ncbi.nlm.nih.gov/pubmed/21426201
http://www.ncbi.nlm.nih.gov/pubmed/19949402
http://www.ncbi.nlm.nih.gov/pubmed/18451877
http://www.ncbi.nlm.nih.gov/pubmed/16362499
Here is a recent review from the American Journal of Physiology:
Am J Physiol Cell Physiol. 2011 Dec;301(6):C1281-9. Epub 2011 Sep 21.
Ion channnels and transporters in cancer. 5. Ion channels in control of cancer and cell apoptosis.
Lehen'kyi V, Shapovalov G, Skryma R, Prevarskaya N.
many thanks for so many usefull suggestion in such a short time. I'll be pleased to get more
Am J Physiol has published a whole series on that topic, starting with the Editorial in 2011: "American Journal of Physiology-Cell Physiology theme: ion channels and transporters in cancer", and still continuing 2012. If you look at scholar google with that clue, you will catch the series.
Hi !
indeed the Am J Physiol is a good series on the topic.
Like already said you sould have a look on the biblio of Annarosa Arcangeli, Luis Pardo and :Walter Stuhmer:
Cancer Res. 2008 Mar 15;68(6):1611-3.
Eag1: an emerging oncological target.
Pardo LA, Stühmer W.
or Natalia Prevarskaya such as:
Trends Mol Med. 2010 Mar;16(3):107-21. Epub 2010 Feb 16.
Ion channels and the hallmarks of cancer.
Prevarskaya N, Skryma R, Shuba Y.
Nat Rev Cancer. 2011 Jul 22;11(8):609-18. doi: 10.1038/nrc3105.
Calcium in tumour metastasis: new roles for known actors.
Prevarskaya N, Skryma R, Shuba Y.
There are also some very good reviews from Harald Sontheimer:
Am J Physiol Cell Physiol. 2011 Sep;301(3):C541-9. Epub 2011 May 4.
Ion channels and transporters [corrected] in cancer. 2. Ion channels and the control of cancer cell migration.
Cuddapah VA, Sontheimer H.
Exp Biol Med (Maywood). 2008 Jul;233(7):779-91. Epub 2008 Apr 29.
An unexpected role for ion channels in brain tumor metastasis.
Sontheimer H.
Hi Elena,
The American Journal of Physiology [Cell Physiology] (August 1, 2011 vol. 301 no.1 C253-C254) began a series of articles on the theme of "ion channels and transporters in cancer" that address the roles of ion channels in cell proliferation, apoptosis etc.and cancer. I think that this series of papers would be a good place to start.
Cheers!
Scott
Hello,
Yes, George is right about Mustapha Djamgoz , who did an extensive work on voltage-gates sodium channels in prostate and breast cancer cells. Here are two interesting reviews:
Eur J Pharmacol. 2009 Dec 25;625(1-3):206-19. Epub 2009 Oct 14.
Molecular pharmacology of voltage-gated sodium channel expression in metastatic disease: clinical potential of neonatal Nav1.5 in breast cancer.
Onkal R, Djamgoz MB.
and
Neuroscientist. 2008 Dec;14(6):571-83. Epub 2008 Oct 20.
An emerging role for voltage-gated Na+ channels in cellular migration: regulation of central nervous system development and potentiation of invasive cancers.
Brackenbury WJ, Djamgoz MB, Isom LL.
On related topics, there are also:
Recent Pat Anticancer Drug Discov. 2007 Nov;2(3):189-202.
Voltage-gated ion channels, new targets in anti-cancer research.
Le Guennec JY, Ouadid-Ahidouch H, Soriani O, Besson P, Ahidouch A, Vandier C.
Curr Pharm Des. 2006;12(28):3681-95.
Voltage-gated sodium channels: new targets in cancer therapy?
Roger S, Potier M, Vandier C, Besson P, Le Guennec JY.
Cheers,
Sebastien
Not for propaganda, but we contributed in this field with a special kind of ion channels:
Wolf F.I. and Trapani V Magnesium and its Transporters in Cancer: a New Paradigm in Tumour Development. Clin. Sci. 2012; Oct 1;123(7):417-27.
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