I'm just wondering if that is possible to simulate microchannel flow behavior in a larger channel with dimensionless parameter scaling of the operating condition
I assume that you are carefully considering the "dynamic similarity" of the two cases (geometrical similarity, equal Re number. In case it is a heat transfer problem, equal Pe number and Pr number in addition to Re). If so, you are fine as long as the governing physics are identical for both cases; microchannel and macrochannel can have different velocity and temperature boundary conditions at the channel walls (when Knudsen number of microchannel is smaller than 0.1, we consider the slip velocity and temperature jump instead of no-slip condition and same solid-fluid temperature). This is the case for rarefied flow in microchannels, so if your working fluid is a liquid, I doubt you face such a condition.
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