Hi everybody,

I am little bit confused about the loss of heterozygosity term. If I understand, we can say there is a LOH when one allele is lost (a wild type allele) in the case of the other allele was already non-functional (like it's the case in a germinal mutation). But when there is, for exemple, a methylation of the promotor of a gene which is on the wild type allele, can we say this is a LOH or not ? And in some articles, authors say we can have a mutation and a LOH for the same locus, so that means mutation can't be an evenement which triggers a LOH ? And is it possible to have a LOH in sporadic cancer ? because I understand the mechanism in hereditary cancer but I don't understand the mechanism in sporadic cancer . Actually, I'm totally confused with all definitions on internet so if you can help me, you will save my life!

Thank you for your help!

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