Looking for the possibilities that might help researchers to find a cure or new dimension of thinking that might help to fight viruses of the 21th century.
Thank you for sharing your thoughts, I agreed that RNAi can be unstable, but the issues can be addressed after the experimentations and study the success ratio for virus degradation,
The cell culture might help for the initial stage. Secondly, other virus-host can be examined to the mechanism of RNAi in the host cell to encounter the viruses.
It is used to treat a completely different disease, however I think the same principle could be also applicable to silence the expression of a viral RNAs. Although I am not an expert on this at all...
Yes it is possible, provided you choose a crucial target for example the sequences involved in the replication of the virus.A topical application through inhalation of such RNA i could possibly stop the spread of the virus in the lungs.
Yes, it is possible to thrive upon RNAi mediated therapies. Previous studies have shown them to be effective for Respiratory Syncytial Virus. But, still these therapeutics are already not well established and there are many drugs in the clinical trials, only a part of which have been approved by the FDA. The following article could be a little related to your query here.
Yes, we can but so far even a single report is not available which can tell how many miRNAs species and their biogenesis pathway are involved in COVID patients. otherwise, this is the best option to inactivate viral RNA by making STTM and MIMIC of particular expressing viral RNAs.