Can we use 100% methanol on slica column?

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El-Sayed M El-Sayed

I think it may dissolve silica gel

In some cases i use 15% methanol/methylene chloride in the end of column but i think more than 20 % may dissove packed silica ,,so what the effect of 100 % methanol can be known

Asmaa Ibrahim

Thank you so much i think so that's why all my components adsorbed on silica and the methanol containing silica

Corentin Bon

https://selekt.biotage.com/blog/does-methanol-really-dissolve-silica-during-flash-column-chromatography

Abd Elmounaim Safer

pure methanol does not dissolve silica

Innus Mohammad

If you use granular silica, it shouldn't be a problem.

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