I have prepared schiff base metal complexes and they are not completely soluble in common organic SOLVENTS, but complexes are partially soluble in DMSO AND DMF
Antimicrobial activity of partial soluble metal complexes should not be taken.When you test the compound it should be soluble completely, You can use DMF or DMSO solvent for dissolving the complexes . Use control of the solvent & subtract the zone of inhibition by the solvent from that of complexes.
Madhukar is completely right. If you want to study the molecular toxicity of a complex seriously, e.g. to compare it to another molecular standard, your complex must be soluble.
You might try to use semi-soluble material, or complexes embedded in material which slowly release them (such as molten algar, polymer particles or MOFS) but then your toxicity behaviour is depending on the release rate. In a serious study this release should occur in a controlled fashion and the rate should be measured.
You can choose the sutiable solvent for completely soluble the metal complexes or choose easily soluble salts of metal ions kike as acetate, chlorides, nitrates and etc....
Please can anyone suggest me, which solvents systems should be used to dissolve metal complexes when they are partially(maximumly) soluble in DMSO AND DMF