Can we separate two diastereoisomers by a classical reversed-phase column C18 or C8?

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Khаlеd Sеkkoum

Thank you Didier

Sibel A. Ozkan

Dear Khaled,

Yes you can separate diastereoisomers. But you cannot separate chiral compounds using these type of columns.

Thank you very much Prof Ozkan

Hassan Y. Aboul-Enein

OF COURSE KHALED SINCE DIASTEREOISMERS HAVE DIFFERENT PHYSICOCHEMICAL PROPERTIES. SO ACHRAL COLUMNS SUCH AS C18 CAN SEPARATE THEM EASILY.

Thank you very much Professor Hassan.