It means that the speed of mutagenesis of a virus increases until it no longer poses a threat to the host due to molecular trade-offs. Considering molecular-orbital perspectives, it makes sense that the inclusion complex's overall energetic profile (nothing else is a virus, chemically speaking) remains constant. It means that mutations are in an internal competition. An advantage at the spike protein thus leads to a disadvantage elsewhere. Viral genetic trade-offs could be targeted for amplification.
This point is reached, for example, due to many transmissions and is accelerated by drugs, vaccinations, and the promotion of mild (or unfit) variants.
What we do to manage mutations?
- Vigorous search for alternative treatment methods (antiviral, antibacterial, polyphenols, dietary changes, etc.) - treat infected people before they enter ICU.
- Promote low-fitness antibody-escape mutants
- Continue with vaccinations (non-pathogenic variants, NPV)
- Search for other elements that increase or decrease SARSCOV2´s fitness (ie polymerase, microbiome, cytokines, cofactors (eg calcium, iron, acetyl choline, histamine....) - basophils and mast cells....
- Suppression of drug-resistant and harmful viral mutants during antiviral drug therapy (....VIRs)
It is a theory, and many have not yet clearly understood how it works.
References:
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1008271
https://link.springer.com/chapter/10.1007%2F82_2015_463
I am agree with this approach, however., it can be examined after seriously overcoming the ongoing war against invisible pandemic with visual catastrophe.
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