If I prepare Eudragit nanoparticles and later convert it to suspension and use it as nasal spray, would it be ok? Remember drug is neither for respiratory tract, or it has to target brain. I have not seen any article so far in which eudragit alone has been used in the nasal route.
From the material safety data sheet, I read that Eudagrit may cause irritation in respiration tract. I suggest you should look for more eferences about it.
You need to check the MSDS of the excipients and also need to check the drug interactions if any.
Information regarding the comprehensive characterization of the physical and
chemical properties of the drug substance should be known as it will be inhaled.
Also acceptance criteria for physicochemical parameters of a qualified polymeric
excipient for nasal spray must be of concern (e.g., molecular weight distribution etc.
Kindly do check all the above and related parameters.
Good Luck
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