Hi Saba

To start with combination of drugs in a single formulation, you should study the incompatibility. Consider all physical, chemical, biological properties. And Stability does matter as you want to incorporate peptide...

Also go through the excipient profile before you select.

And i am interested to know, the reason for this combination.

Multiple compounds can be encapsulated in solid Lipid Nano particles by considering all the incompatibility parameters of interesting compounds.

Of course, yes. We can encapsulate two different compounds simultaneously within the same SLNPs. Since SLNPs consist of a non-polar lipid core surrounded by a layer of surfactant molecules and it is this core only, which is capable to hold both the peptide antigen as well as TLR 7 agonist (Imiquimod) together because of their hydrophobic nature which matches with the nature of SLNPs' core.