Can urea (1M - 10M) in samples interfere or give false results for HPLC analysis of polyphenols (PACs in specific)?

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Mahboubeh Saeidi

Urea is hydrolyzed in aqueous solution slowly and pH of solution may changed.

Nathalie Plundrich

Thanks Mahboubeh!

That actually would make sense I think. Do you have a reference (paper) supporting this by any chance?

Thanks!

Nat

About this subject you need to read books of fundamentals of Analytical chemistry for example: Skoog&West, Christian...(section of classical not instrumental analytical chemistry of above books).