I work with carboxymethyl cellulose and CTAB to form aggregates, and the next step is functionalizin., Does someone have experience in the amidation process of carboxyl groups? Which is the best reagent for it? Which is the best and easiest procedure?
Do you have any experience on direct amidation of carboxylic acid in different media?
I can introduce some of effective procedures for amidation of the carboxyl groups.
No, I never have done that. Chemists friends suggest me first to do the amidation of CMC, then realize the synthesis.
(For the synthesis I use water like solvent)
You can apply different methods: First, Carbonyldiimidazole (CDI), this reagent used to link carboxyl group to amine group. This is a non-aqueous reaction.
Second, N -hydroxysuccinimide (NHS), NHS ester crosslinking reagents couple principally with the alfa-amines at the N-terminals.
Third, NHS esters also may be formed in situ to react immediately with target molecules in aqueous reaction media. Using the water-soluble carbodiimide EDC.
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