Can SIRT2/6-IN-1 be used in animal experiments?

2 weeks ago 1 2K Report

Hello everyone, may I ask what the dosage of SIRT2/6-IN-1 (HY-123194, MCE) is for intraperitoneal injection in rats? We have read many references but were unable to find the exact dosage for rats.

Wang Ting Ting

Hi,

There are very few literature reports on this product currently. We have not found any literature on its administration in rats, but we have identified relevant studies in mice, which you may refer to. Generally, based on dosage conversion, the dosage for rats is 1/2 of that for mice; however, dosages may vary depending on the experimental model, so it is recommended to explore both high and low dosage groups.

PMID: 35150745

The answer to this question is provided by MedChemExpress Technical Support. [email protected]

Badges
Science topic

More Yan Yan Zhao's questions See All

Whether i can preserve leaves samples in 2.5% glutaraldehyde in 0.05 M phosphate buffer, pH 7 for coming several weeks for further LM study ?

I want to preserve the sample leaves for the LM study of the stomata and conidia analysis. Whether 2.5% glutaraldehyde in 0.05 M phosphate buffer with pH 7 can be applied for preservation.

29 July 2024 8,560 0 View

Is CFI / TLI = 1 okay in Mplus?

Hi there, I did a CFA to 10 items on 2 latent variables. The model fit is too good and I've never seen it before. CFI / TLI = 1, RMSEA = 0. Is it okay, if everything else was done properly?...

24 July 2024 5,454 7 View

What is the function of fusion tag GAMGSGIQRPTST?

I found that several expression constructs of published protein structures containing an N-teiminal fusion tag GAMGSGIQRPTST. What's the founction of this fusion tag?

23 July 2024 1,353 4 View

How to perform immunofluorescence on suspension cells?

Some time ago, I wanted to perform immunofluorescence on the S protein of mouse CD4 T cells using a Leica super-resolution microscope. I fixed with 4% paraformaldehyde, then added it to the well...

20 July 2024 3,797 2 View

What analysis to use for an dependent variable with repeated measures and a independent variable only measured once?

Hi all, I am trying to use mixed effect model to analyze my data, which including a baseline measurement for my exposure (A), and repeated measurements for the outcome (B). I do have some...

17 July 2024 8,682 3 View

What is the most simple language and character in the world?

Dear colleagues, As well known, we can deliver messages in different languages and characters, including Chinese, English, Latin, binary and decimal codes (if with a converter) and many other...

08 July 2024 5,422 13 View

How do I link researchgate with my pubmed publications?

I moved to a different institute and changed my email address. Somehow I lost the list of my publications. Is there a way to link to my PubMed publication list?

17 June 2024 5,312 2 View

How to image cells on inserts with Cytation 5?

Hello, I am experimenting to grow cells onto permeable membrane support (inserts) in a 12-well plate. The cells are stained with DAPI. Just wondering how to image the cells attached to the inserts...

20 May 2024 1,061 0 View

How to remove sulphur from the surface of nanoparticles?

Use of thioglycolic acid as a stabiliser during the synthesis of nanoparticles

05 May 2024 9,109 1 View

What mode can confocal microscopy use to observe metal surfaces?

How can confocal microscopy observe cells stained on metal surfaces

28 April 2024 2,804 1 View

Can I multiplex a mouse monoclonal and rat primary for IHC (mouse brain tissue)?

Hi all, I was just wondering if anyone has experience with multiplexing a mouse monoclonal primary and a rat primary. I'm trying to multiplex by incubating them in the same well but was told by a...

06 August 2024 9,710 1 View

In what part of the brain´s rabbit bdnf is located and include references please?

I´ve been unable to find specific information about this neurotrophin in the CNS of rabbits exclusively. There is extensive info in mice, fish and rats, but in brain´s rabbit is hard to find....

04 August 2024 762 1 View

What can be the minimum number of animals (rats) to be used for a pilot/preliminary study on intradermal drug delivery?

Dear All I would like to know the minimum number of animals (rats) to be studied for a pilot/preliminary research on intradermal drug delivery. Can I proceed with 1 animal per group for a pilot work?

02 August 2024 4,570 1 View

CAD File of human's & rat's respiratory airways ?

Dear all, I am working on particle deposition in human's & rat's respiratory airways using CFD and I am looking for the 3D CAD file for my simulations (STEP or IGES format). If somone has such...

29 July 2024 1,092 2 View

Could GSH level be more in CCL4 rats than negative control rats?

i compare between the antioxidant and oxidative stress level between negative control rats (saline) and CCL4 intoxicated rats. i found the level of GSH and TAC is more in toxic group than normal....

26 July 2024 1,887 0 View

Does Fentanyl presence in injecting drug user communities require special harm reduction measures?

With Fentanyl already being detected in some countries in Europe, I believe many of us are not educated enough on special needs of injection drug users that use Fentanyl, due to its high strength...

08 July 2024 7,694 3 View

What is the anti anaemic potentials of hibiscus sabdariffa on wister rats?

anti anaemic potentials if hibiscus sabdariffa

01 July 2024 8,429 0 View

What is the best method to measure diameter of new vessels in tissue,e.g. spinal cord?

Hello! I would like to study newly formed vessels after spinal cord injury in rats. However, I do not know what is the most suitable method to check diameter or number of vessels and which...

01 July 2024 9,744 0 View

Calculating the injection volume for a mouse?

I will be administering 5-fluorouracil at a dosage of 50 mg/kg to mice as an I/P injection. Will someone please check my calculation? (Mw: 130.078 g/mol) Max volume to be administered to mice I/P...

23 June 2024 3,847 1 View

Which pH range is allowed for subcutaneous pump administration?

Hello, We are designing a protocol to determine the effect of certain compounds in the health of rats, but our problems have certain instability issues when subjected to certain pHs. We were...

19 June 2024 5,950 1 View