I'm investigating scRNA-seq as a way of measuring how different cell types respond to virus infection. To do this the transcriptome would be used to determine 1) cell type and 2) virus infection. Many viruses are notorious for suppressing host transcription, which might interfere with transcriptome analysis. All scRNA-seq data I've found with virus infection is done in cell lines or flow sorted cells (supporting my suspicion). Has anyone done scRNA-seq in virus infected organoids, tissues, mixed cells, etc. or can anyone point me toward useful publications?
Hope this might help you sir..Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses...check on the linkArticle Single cell RNA sequencing of 13 human tissues identify cell...
Thanks for the answer Buvnesh, but the scRNA-seq datasets they analyzed were from uninfected tissues. I'm looking for scRNA-seq studies with virus-infected tissues.
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