It is said that there is a somewhat clear correlation between plasma and salivary levoflaxin concentration in MDR-TB patients and yet other researchers contest that there are very low concentrations of drug analytes appearing in the salivary matrix.
To answer this question, further readings into studies conducted to find out whether or not salivary matrixes could be an alternative for antiepileptic TDM would be beneficial. In terms of traditional linelozoid TDM, salivary matrix can be used as an alternative however, there are limitations on the uage of saliva universally for TDM, such as is the case of moniflaxin TDM, which does not support saliva, according to the study (Therapeutic drug monitoring using saliva as matrix: an opportunity for linezolid, but challenge for moxifloxacin, Elsen et al., 2019).