Please can you provide some more details. Your question is far too vague to provide a useful answer.
What is the surface that you will immobilize the cells/enzymes on? What are the dimensions of this surface? What is the end application? Do you have details of the cell/enzyme you wish to immobilize?
There are many approaches to achieve immobilization, all with pros and cons.
Please try to go through literature before bringing up questions in research gate. Some of the questions are really embarrassing and suggestive, at first glance, of the un-seriousness of this platform, which I know it isn't. There are way too many articles on immobilization, whether of whole cells or enzymes. The pros and cons, like Jules said, are all well detailed. No hard feelings please.