This is a question regarding oxytocin and Redox reactions.
Cyclic oxytocin has a disulfide bond. As far as I understand this is the oxidised form.
Linear oxytocin has two thiols. As far as I understand this is the reduced form.
(Update: Does the current known linear oxytocin still have a disulfide bond because it is cleaved at Tyr-Cys?
Does this mean that reduction would lead to a disulfide break which would essentially form a new type of oxytocin: linear-thiol-oxytocin?)
Can nitric oxide oxidise linear oxytocin to form cyclic oxytocin in the blood?
Thank you for any answers.
Phuoc-Tan
Dear Phuoc-Tan Diep in this context, the following PhD thesis might give you some useful information:
EVALUATION OF OXYTOCIN PHARMACOKINETIC / PHARMACODYNAMIC PROFILE AND ESTABLISHMENT OF ITS CARDIOMYOGENIC POTENTIAL IN SWINE
https://papyrus.bib.umontreal.ca/xmlui/bitstream/handle/1866/4266/Ybarra_Norma_2010_these.pdf?sequence=2&isAllowed=y
The thesis is freely available as public full text (see attached pdf file).
Oxidation reactions of thiols with nitric oxide (NO) are often more complex, but they can in fact afford the corresponding disulfides under certain conditions. For typical papers on this topic please have a look at the following references:
Oxidation and nitrosation of thiols at low micromolar exposure to nitric oxide. Evidence for a free radical mechanism
Article Oxidation and nitrosation of thiols at low micromolar exposu...
Oxidation of thiols by nitric oxide and nitrogen dioxide: synthetic utility and toxicological implications
Article Oxidation of thiols by nitric oxide and nitrogen dioxide: Sy...
and
Superoxide Modulates the Oxidation and Nitrosation of Thiols by Nitric Oxide-derived Reactive Intermediates: CHEMICAL ASPECTS INVOLVED IN THE BALANCE BETWEEN OXIDATIVE AND NITROSATIVE STRESS
Article Superoxide Modulates the Oxidation and Nitrosation of Thiols...
The latter article has been posted as public full text on RG and can be freely downloaded as pdf file.
Good luck with your research and please stay safe and healthy! 😊
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