It works in mice just fine - here is an example: https://hookelabs.com/services/cro/eae/MOGCFA-inducedEAEinC57BL6mice.html

Yes, it will work.

Hi Hamidreza,

As Vadim and Georgina said, FTY720 or fingolimod will work in EAE mice model. Sphingosine 1-phosphate receptor (S1PR) is expressed in mouse T cells. Thus, in the same way as the human disorder, EAE animal model will ameloriate with fingolimod. I attach a paper from 12 years ago that describes these effects in the animal model.

Kataoka, H., Sugahara, K., Shimano, K., Teshima, K., Koyama, M., Fukunari, A., & Chiba, K. (2005). FTY720, sphingosine 1-phosphate receptor modulator, ameliorates experimental autoimmune encephalomyelitis by inhibition of T cell infiltration. Cell Mol Immunol, 2(6), 439-448.

I hope you find it useful!

Regards,

Jordi.