I am injecting a substance by a dose of 4 gm/kg body weight. It is soluble in normal saline. Unfortunately after several tries I need 2.5 ml of saline to completely dissolve 1gm of this substance, which results in a large amount of solution to be injected ip: from 2-3ml saline for 250-320 gm rat, Is that applicable?
Sara Elfarrash
I am not an expert here but i would say it is too much. But it may also depends on how many you need to do the injection if this is only the way you can get to the final dose.
But i have never tried to inject that much volume in mice. I usualy stick to not more than 1 ml.
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Abdelaziz Mohamed Hussein
I think its too much nedaa as the total blood volume in a rat with this weight 7 ml , it is better to be given iv via infusion pump for 2 hours
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