Can I find molecular weight of PLGA based formulation with respect to time when subjected to in-vitro release using viscosity as a measurement tool?

12 November 2021 1 4K Report

I want to find out degradation rate of PLGA formulation w.r.t. time for which change in initial molecular weight would be beneficial. Moreover, I don't have GPC facility. Please help me if anyone has worked previously in this regards.

Matheus Mendes

If I understand correctly you can use an Rheometer and use Mark-houwink Sakurada equation to discover the Mw of your PLGA, but you will need a Rheometer.

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