A patient took 4500 mg acetaminophen in 3 days span along with the following drugs prescribed by a homeopath practitioner- Arsenic, Calcium Sulphide and Bryum album (dipped in alcohol). He developed Fulminant Hepatic Failure SGPT rocketed from 1158 U/L to 3796 U/L overnight. No virus detected. Can acetaminophen do such damage at so low dose?
It is very possible that it has happened due to drug interactions plus acetaminophen idiopatic (genetic) hipersensibility. On the other hand, there are cases in literature refering hepatic failure with low doses of acetaminophen. It would be important to know the clinical antecedents of the patient. Is SGTP 1158 the base value you got?
complex interaction between paracetamol and alcohol intak
the acute administration of ethanol inhibits the potentially toxic oxidative metabolism of paracetamol and protects against liver damage. This protection decreased when the concentration of ethanol decreased.the critical period is that the time between ethanol and paracetamol intak
while chronic alcoholism, microsomal enzyme induced with increased toxic metabolic activation of paracetamol and enhanced hepatotoxicity. elevation of SGOT/SGPT ratio may be 5 times greater than normal
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