I want to study mode of action of a medicine used in traditional system of healing and want to check its mode of action. I will be doing my studies on mice models but do not wish to study mode of action in vivo. can HeLa cells be used?
I do not know much about it but following papers may be useful to you.
1) Small Molecule Antagonizes Autoinhibition and Activates ...
www.ncbi.nlm.nih.gov › ... › J Biol Chem › v.283(23); Jun 6, 2008
by T Pang - 2008 - Cited by 82 - Related articles
2) Transporter-Mediated Drug–Drug Interactions with Oral ...
www.ncbi.nlm.nih.gov › NCBI › Literature › PubMed Central (PMC)
by S Klatt - 2011 - Cited by 6 - Related articles
3) Cell Death and Disease - Metformin lowers Ser-129 ...
www.nature.com › Journal home › Archive › May 08 2014
by BI Pérez-Revuelta - 2014 - Cited by 1
4) ]A Multi-Assay Approach to the Study of Cellular Toxicity
www.gene-quantification.de/qpcr2009/Shipley-qPCR-2009.pdf
"I will be doing my studies on mice models but do not wish to study mode of action in vivo. can HeLa cells be used?"
There are several forms of diabetes and each effects a large number of aspects of the individual affected by it.
You must first consider which type of diabetes interests you and then contemplate what specific aspect of diabetes you wish to study. Note if the HeLa cells possess all the necessary mechanisms to emulate the target organ/cell that you wish to study in a "diabetic" and if the answer will tell you whether or not you can.
thank you Tausif Alam. i wish to study both type one and two diabetes.
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