Polyphenols like Quercetin or curcumin are best consumed in lipid medium like Ghee (clarified butter) for better bio-absorption/ availability- i.e. non-polar (hydrophobic medium)- https: //www.mdpi.com/1420-3049/27/21/7631 & https: //pubmed.ncbi.nlm.nih.gov/25761771/ (plz. delete gap after "://" to click & read it). Methanol is pro-polar but is useful to extract polyphenols fare more than water-https:// www.ncbi.nlm.nih.gov/pmc/articles/PMC6273793/ Rashmi Tripathi ji