If you will cover nanoparticles with kind of polymer - eg PE, what will enlarge nanoparticle - seems it make sense (if you will put nanoparticles in polyethylene jar toxicity will be zero; using other words: you will change size from nano to higher size). The one of the problem with nanoparticles is their small size which allows them to pass through cell walls and sometimes cause gene damage.

Of course, coating with suitable materials may prevent toxicity in practice

Dear Abdelhak Maghchiche

You asked about the possibility of encapsulation or coating of nanoparticles in preventing toxicity while maintaining efficacy. Yes, there are many successful trials solved the problems associated with this. In [1], polymer coatings are used, which are an effective way to reduce the apparent toxicity of nanoparticles. The biocompatible one of polymer coatings was found not only prevent the body’s immune system from reacting adversely to foreign materials but also promote healing and integration of the device into surrounding tissue, leading to a more favorable clinical result, as you can seen in [2]. Also , In [3] you can stand on the , delivers them directly to the target site, and releases them in a controlled manner. My best regards .....

[1] Article Methods for Reducing the Toxicity of Metal and Metal Oxide N...

[2] https://www.proplate.com/biocompatible-coatings-that-mitigate-allergic-reactions-in-implantable-devices/

[3] https://www.sciencedirect.com › science › article › pii