I require a Friedel-Crafts reaction with chloromethyl pivalate as my reagent, and an alkyl benzene - I couldn’t find any literature on this reaction on the web. I was wondering if anyone had any experience with beta-haloesters/ketones undergoing Friedel-Crafts?
Thank you!
Filip Latkovic
Do you mean as alkylating agents? I don't thinK so. By using a Lewis acid as a catalyst you can hardly form a stable carbonium ion. Otherwise, the presence of a carbonyl group in the reagent is another inconvenient, even using the catalyst in excess. But you can try...
Yeah, as alkylating agents for the FC alkylation of an arene ring. Carbonyls aren’t a problem if an excess of Lewis acid is used, as I’ve seen in a couple of reactions I did before, but the carbonium stability is definitely a problem.. I could try forcing conditions, and see how it works. Thank you!
I am not sure, but this reagent can undergo intramolecular rearangement in the presence of Lewis acids.
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