Can bacteriophages be used against biofilm forming within indwelling medical devices in-vivo?

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SEDDIKI S.M.L

Hello,

I think it is too early to do tests in vivo, but an animal model would be very interesting to verify your hypothesis. However, you have to be sure that the medical device is contaminated with biofilm and that the latter also be contaminated by the bacteriophage.

Moreover, the phage could be dangerous for the host, It would be better to check this before.

good luck for the future, S.M.L. SEDDIKI

Houda Kawas

Dear Vikrant Negi

Pls. find the attached files and the references, good luck

Hoping this will be helpful to your project

Regards

http://journals.lww.com/asaiojournal/Abstract/2000/11000/Role_of_Biofilms_in_Antimicrobial_Resistance.37.aspx

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798481/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2732559/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348827/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1426991/

http://aac.asm.org/content/54/1/397.full

https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/femspd/59/3/10.1111_j.1574-695X.2010.00696.x/1/59-3-447.pdf?Expires=1502997082&Signature=ffzywAz6oY4nRbeGucd8OoriNb~NuQnrD9aaonF3e8zMpWQScA9LsQTJKrhUHb9ZhiM2hZpkGmTM5szCTiPBOQSkcktiEg8wBiqDscaOpS7jzI9N7k~~lsNXz7Xq3NKCWVud2IJKKPlD3n~XWBEtNUin4uXcwy7h0Za9Bg7wHqXjSEDk546vKvVf1de3EyMWCSVzv-F9KBnlvjgq98r9FZ1baknt6~jj8QRL0wFK~wdCd0n9A4NQzlvlpwxUC2z1RHjtchMTWRTCi1bfRf9Tmltp-9tkwdorPuYoewKtUFn8fq2ZAxZzoW01HC98dbMx9M4bxYtyTNJTcR1Ofm3R-w__&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Q

http://www.emergtoplifesci.org/content/early/2017/04/06/ETLS20160020

http://www.microbiologyresearch.org/docserver/fulltext/jmm/64/4/323_jmm000032.pdf?expires=1502904387&id=id&accname=guest&checksum=8584F08E58A2C92E6CB232443ABDBFE9

http://www.nature.com/ijos/journal/v7/n1/full/ijos201465a.html?foxtrotcallback=true

Vikrant Negi

Thank you Dr Houda Kamas for these references.