I obtained silk from bombyx moori after lithium bromide treatment. The aqueous solution I get solidifies when I try to mix the drug in it using magnetic stirrer which is very difficult to use for electrospinning. How can I get rid of the problem?
Dear Muhammad Samie
How much quantity of Drug you are adding with the silk solution?.
Try this method:
1. Buy silk cocoon and dewax it.
2. Use THF as solvent and mix the drug and silk with it.
3. You are now ready to spin.
All the Best.
In addition to the previous suggestions, you have to check the effect of pH of the drug solution and whether it contains certain salts which may affect the physical properties of the final solution.
Thanks for your answers.
Oliver Dieste my drug is water soluble and I want to dissolve it in the silk solution before spinning.
Arun Karthick I am using 10%, 20% and 30% drug of the total silk contents by weight.
If the drug is water soluble it won't dissolve in silk solution, if the drug nature is fine powder then you can disperse it and spin as such
I am using the regenerative solution of silk as such and its water based so why the drug won't dissolve in it?
The problem is that the regenerative solution get solidified as it is shaken.
Arun Karthick I dewaxed the silk cocoons in aqueous sodium carbonate solution at a temp of 100 for 30 min. After drying the silk at 37 C, I am trying to dissolve it in THF but no result after 12 hrs stirring.
Dear Muhammad Samie
1. Follow this protocol Na2CO3 of 2% and 20% of soap solution (for eg. 20g in 100ml of water) mix it well and raise the temperature to 40-50 C.
2. Add the silk cocoons and keep it for 1 h under mild stirring.
3. then rinse the silk fibers 2 to 3 times in normal distilled water and dry it 45 C.
All the best.
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