Can anyone tell me about the action mechanism of gold nanoparticles in the treatment of rheumatoid arthritis?

09 September 2013 1 4K Report

Rheumatoid Arthritis

It appears (!) that Au NPs inhibit proinflammatory cytokine synthesis (especially interleukin 1) which is manifested in in inhibitory effects on bone erosion and joint destruction in RA. There is no clear picture even though gold has been used extensively in treating RA. Empirical methods, mostly... The following articles may be helpful:

Michael J. Abrams and Barry A. Murrer, "Metal Compounds in Therapy and Diagnosis", Science, Volume 261, 725-730 (1993)

Sanders, M., "A review of controlled clinical trials examining the effects of antimalarial compounds and gold compounds on radiographic progression in rheumatoid arthritis", JOURNAL OF RHEUMATOLOGY 27(2), 523-529 (2000)

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