Dear all, I am Rajaram.
At present I am doing depression studies on animals. I also want to check the same in vitro on cell lines. If any cell lines are there (like BV-2 microglia) please suggest some cell lines. Which is the ideal cell line for checking the LPS-induced depressive like behavior in vitro?
Thanks in advance..
Dear Rajaram,
Check these papers out, they may give you some ideas:
Attenuation of neuroinflammatory responses and behavioral deficits by Ligusticum officinale (Makino) Kitag in stimulated microglia and MPTP-induced mouse model of Parkinson׳s disease. Kim BW, Koppula S, Park SY, Kim YS, Park PJ, Lim JH, Kim IS, Choi DK. J Ethnopharmacol. 2014 Nov 11. pii: S0378-8741(14)00778-8.
Acetylsalicylic acid enhances the anti-inflammatory effect of fluoxetine through inhibition of NF-κB, p38-MAPK and ERK1/2 activation in lipopolysaccharide-induced BV-2 microglia cells. Yang JM, Rui BB, Chen C, Chen H, Xu TJ, Xu WP, Wei W. Neuroscience. 2014 Sep 5;275:296-304
Neuroinflammation. 2013; 10: 142. Neurovascular unit dysfunction with blood-brain barrier hyperpermeability contributes to major depressive disorder: a review of clinical and experimental evidence
Souhel Najjar et al.
Phenelzine (monoamine oxidase inhibitor) increases production of nitric oxide and proinflammatory cytokines via the NF-κB pathway in lipopolysaccharide-activated microglia cells. Chung HS, Kim H, Bae H. Neurochem Res. 2012 Oct;37(10):2117-24.
Acorus gramineus inhibits microglia mediated neuroinflammation and prevents neurotoxicity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of Parkinson's disease. Jiang J et al. J Ethnopharmacol. 2012 Dec 18;144(3):506-13.
Green Tea Extract Ameliorates Learning and Memory Deficits in Ischemic Rats via Its Active Component Polyphenol Epigallocatechin-3-gallate by Modulation of Oxidative Stress and Neuroinflammation. Wu KJ, Hsieh MT, Wu CR, Wood WG, Chen YF. Evid Based Complement Alternat Med. 2012;2012:163106
Biol Psychiatry. May 1, 2009; 65(9): 732–741.
Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression
Andrew H. Miller et al.
JHistol Histopathol. 2004 Apr;19(2):535-64.
Structural pathways for macromolecular and cellular transport across the blood-brain barrier during inflammatory conditions. Review.
Lossinsky AS, Shivers RR.
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