Hi Paresh,
Cancer cells are different from normal cells by the loss of density-dependent inhibition of growth, decreased adhesiveness, loss of anchorage dependence, and invasiveness through normal tissue barriers.
Number of changes in the biochemical characteristics of malignant cells' surfaces have been observed. These include appearance of new surface antigens, proteoglycans, glycolipids, and mucins, and altered cell-cell and cell-extracellular matrix communication.
check this article.. https://www.ncbi.nlm.nih.gov/books/NBK12516/
Good Luck..!
Cancer cells usually overexpress different cell surface receptors like EGFR or insulin receptors, and particularly certain channels like VGSCs and surface enzymes like carbonic anhydrase IX and XII. Vacuolar ATPase Proton Transporters and NHE-1 are very often overexpressed. The external surface of the cancer cell is highly acid due to proton extrusion. This does not happen in normal cells. You have to add these differences to those that Susara has described.
PD1 is also missing in the list.
CTLA 4 and PD1 explain immunoescape of tumor cells.
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