Can anyone suggest any kits or reagents which may help me in removing dsRNA contaminants after In-vitro Transcription (IVT reaction)?

Chaitanya Naimesh Parikh @Chaitanya-Parikh-3

05 July 2022 1 6K Report

I am generating mRNAs for intra-tumor injections in mice. I want to reduce non-specific immunogenicity due to dsRNA contaminants after IVT. Any simple protocols or kits which could ensure purification of ssRNA only? Please suggest.

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