Has anyone measured the concentration of muscle glycogen with a different protocol to biopsias?
13C-magnetic resonance spectroscopy is a fairly commonly used procedure.
Would be the RMN-C able to measure mimimal changes at skeletal muscle after carbohydrate overload (1 day pre and post)?
This article may help you answer your question:
Reproducibility and Absolute Quantification of Muscle Glycogen in Patients with Glycogen Storage Disease by 13C NMR Spectroscopy at 7 Tesla
Katja Heinicke,#1,2,* Ivan E. Dimitrov,#3,4 Nadine Romain,1 Sergey Cheshkov,3 Jimin Ren,3 Craig R. Malloy,3 and Ronald G. Haller1,2,5
In addition fine needle aspiration may be another avenue, its less invasive- see below
Fine needle aspiration coupled with real-time PCR: a painless methodology to study adaptive functional changes in skeletal muscle.
Guescini M1, Fatone C, Stocchi L, Guidi C, Potenza L, Ditroilo M, Ranchelli A, Di Loreto C, Sisti D, De Feo P, Stocchi V.
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