Saudi anti-human cancer plants database (SACPD): A collection of plants with anti-human cancer activities:
Saudi anti-human cancer plants database (SACPD) comprises the scientific and local names of 91 plant species that grow naturally in Saudi Arabia.
SACPD will provide an excellent starting point for researchers and pharmaceutical companies who are interested in developing new anticancer drugs. SACPD is available online at https://teeqrani1.wixsite.com/sapd
Article Saudi anti-human cancer plants database (SACPD): A collectio...
Flavonoids, Curcumin, Vit. E. For control purpose, you use either of the former two.
Vincristine,Catharanthus roseus, commonly known as the Madagascar periwinkle, etoposide and teniposide derived from the lead compound podophyllotoxin; numerous analogs derived from taxol; topotecan, derived from camptothecin; and the synthetic clinical candidates, E7389 and HTI-286, developed from the marine leads, halichondrin B and hemiasterlin.
The answer really depends on the experiment you want to perform. What outcome do you intend to measure: Induction of apoptosis? Inhibition of cell proliferation? Inhibition of carcinogenesis? Is it to be used in vitro or in vivo? Without supplying these details, most answers can be misleading.
I agree with Mezencev: the question is quite confusing: what is the expected outcome and what is the experimental compound to be tested? In vitro o in vivo? Indeed, thee is plenty of "natural substances" (GSE extracts, curcumin, bioflavonoids, sulphoranate, inositol, bioflavonoids, quercetin, gallic acid, ellagic acid, etc..) that can be used. Eventually: what is the target? colon bresat, lung cancer cells? Whitout providing such details it would harsh to provide a compelling answer
Mariano
There is one more natural compound, thymoquinone, originated from Nigella sativa, as well as turmeric is having great impacts on many cancers.
"Paclitaxel", "vincristine" and "vinblastine" are the three well known natural anticancer compounds. Paclitaxel is obtained from Taxus spp., while vincristine and vinblastine are obtained from Catharanthus roseus.
Hello, parasporins from entomopathogenic bacilli.
https://www.google.com/amp/s/www.researchgate.net/post/Any_news_in_mechanism_of_action_of_Parasporins/amp
Camptothecin is also a well known anti-cancer compound obtained from the Chinese tree Camptotheca acuminata.
Article The long story of camptothecin: From traditional medicine to drugs
Vinca alkaloids are a subset of drugs obtained from the Madagascar periwinkle plant. They are naturally extracted from the pink periwinkle plant, Catharanthus roseus G. Don and have a hypoglycemic as well as cytotoxic effects.
There are four major vinca alkaloids in clinical use: Vinblastine (VBL), vinorelbine (VRL), vincristine (VCR) and vindesine (VDS).
The flowers of Catharanthus roseus G. Don. Catharanthus roseus (syn. Vinca rosea) an evergreen shrub, it grows to a height of 1 m with a spread of 1 m. The stem is short, erect and branching; the leaves are glossy green, oval, 5 cm long and opposite acuminate; the flowers are soft pink, tinged with red, 5 petal, open, tubular and 4 cm across, appearing in spring and autumn .
The main mechanisms of vince alakaloid cytotoxicity is due to their interactions with tubulin and disruption of microtubule function, particularly of microtubules comprising the mitotic spindle apparatus, directly causing metaphase arrest.
Taxanes
Paclitaxel (Taxol®) is obtained from the bark of the Pacific Yew,
Taxus brevifolia Nutt. (Taxaceae).
Docetaxel (Taxotere ®), a semi-synthetic derivative of paclitaxel was found more effective. Docetaxel can be used in patients who are resistant to paclitaxel. Both docetaxel and paclitaxel are used as first- and second-
line treatment in patients suffering from metastatic cancer, brea
st cancer and ovarian cancer.
Camptothecin, an alkaloid isolated from the Chinese tree Camptotheca acuminate, is a potent cytotoxic agent, acting by the inhibition of DNA topoisomerase I. Numerous derivatives of camptothecin have been synthesized in order to improve its pharmacological profile for effective anti‐tumour drugs
Topotecan is found clinically effective in patients with epithelia
l ovarian cancer and small cell lung cancer as a second-line
treatment .
Irinotecan acts as first- and second-line treatment for metastatic colorectal cancer is yet another new camptothecin (CPT) derivative which
demonstrated potential anti-tumor activity against various tumors both in-vitro and in-vivo
http://www.ajcr.us/files/ajcr0067986.pdf
http://eknygos.lsmuni.lt/springer/557/171-190.pdf
Berbamine
Berbamine, a bisbenzylisoquinoline alkaloid was isolated from the Chinese herb named Berberis amurensis. It was reported that Gleevec was responsible for bcr/abl tyrosine kinase inhibition and therefore used in the
treatment of chronic myeloid leukemia. But few patients developed resistance against this drug.
Berbamine has been found to selectively induce cell death of both
Gleevec -sensitive and -resistant Ph+ CML cells. The compound has also been found to display selective anti-proliferative activity of primary leukemia cells from CML patients.
Article A review on berbamine–a potential anticancer drug
Please also see the below given link.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275022/pdf/ijms-19-03533.pdf
Dear Dr. Arvind Singh that is right the modern chemotherapy utilises many substances of plant and aquatic origin. These compounds have cytotoxic properties with many different mechanisms of action, such as the inhibition of tumour cell growth, the induction of apoptosis, DNA damage, the inhibition of topoisomerases I and II, theinduction of apoptosis, and others.
Anticancer properties of Malaysian herbs:
Article Anticancer properties of Malaysian herbs: a review
Anti-cancer natural products isolated from chinese medicinal herbs
In recent years, a number of natural products isolated from Chinese herbs have been found to inhibit proliferation, induce apoptosis, suppress angiogenesis, retard metastasis and enhance chemotherapy, exhibiting anti-cancer potential both in vitro and in vivo.
Article Anti-cancer natural products isolated from Chinese medicinal herbs
Estonian folk traditional experiences on natural anticancer remedies: From past to the future:
44 different plants with potential anticancer properties were elicited, 5 of which [Angelica sylvestris L. (Apiaceae), Anthemis tinctoria L. (Asteraceae), Pinus sylvestris L. (Pinaceae), Sorbus aucuparia L. (Rosaceae), and Prunus padus L. (Rosaceae)] have not been previously described with respect to their tumoricidal activities in the scientific literature, suggesting thus the potential herbal materials for further investigations of natural anticancer compounds .
Article Estonian folk traditional experiences on natural anticancer ...
Traditionally Used Anticancer Herbs In India:
The rate with which cancer is progressing, it seems to have an urgent and effective effort for making good health of humans as well as animals.
There is a broad scope to derive the potent anticancer agents from medicinal plants, which need thorough research.
(10) (PDF) Traditionally Used Anticancer Herbs In India. Available from: https://www.researchgate.net/publication/305386863_Traditionally_Used_Anticancer_Herbs_In_India [accessed Oct 27 2019].
Anticancer Evaluation of Plants from Indonesian Tropical Rain Forests :
The anticancer activities of medicinal plants from Indonesia’s tropical rainfo
rests were investigated against Hela cell line. Maytenfoliol from leaves of
Calophyllumtetrapterum 3-epibetulinic acid from stem bark of C. tomentosum
Wight and D.A-friedo-oleanan-3-on from stem bark of C. moonii showed antic
ancer activity.
(10) (PDF) Anticancer Evaluation of Plants from Indonesian Tropical Rain Forests. Available from: https://www.researchgate.net/publication/323191140_Anticancer_Evaluation_of_Plants_from_Indonesian_Tropical_Rain_Forests [accessed Oct 27 2019].
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