I am currently working on an experiment on how a supplement is influencing the state of chronic stress. I am aware of cortisol measurement but I am in a search of a physiological measurement focused on a stress experienced over a prolonged period of time.
Any suggestion is appreciated! Thank you.
What do you want to mensure, anit-stress behaviour, depression, proteins, neurotrofins?
you can do a mensure of melatonin, tyrosinase and other neurotransmitter.
Epinephrine, and norepinephrine are also part of the stress response. You should also consider some of the counter stress hormones as well, e.g. dopamine, serotonin, and oxytocin. The balance may be more important than the actual concentration.
You may also want to measure heart rate variability. This is a good indicator of stress. A ratio of stable rate to unstable rate over a 24 hour period may be a good indicator of how much stress is experienced each day.
Hi Velina,
I study chronic stress in rodent dams and offspring, but mostly focus on behavioral effects. Ecologically speaking, and intense stress will often result in decreased growth and/or a decrease in body weight. To some degree, we need to know what type of stress you are using and what the specific objectives are. In addition to cortisol (basal as well as stress induced levels), you could look at cort receptor methylation. Adrenal weights may change, but that is a somewhat crude measure that requires a robust stressor. In addition to the hormones mentioned previously, immune and growth factors (such as IL-6, TNF, BDNF and neurosteriods) are often altered by chronic stress. If you are looking at the brain, you could examine glial activity, neural connectivity, and gene expression/methylation of numerous factors in many different regions. As mentioned, heart rate variability is a good option as well, but this can be expensive if you require cardiovascular telemetry.
If you are working with rodents, you could evaluate their behavior in the forced swimming test. Chronic stress induces a passive behavior (floating) in the rodents and some treatments (substances, hormones, etc) reduce this passive coping.
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I advice you to measure the plasma level of inflammatory signaling proteins
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