I have synthesized silver nanoparticles coupled with drug molecules from plants. I want to test it's efficacy on liver cirrhosis (induced) in mice models. Which route of drug delivery can be employed for this purpose?
Thank you Dzmitry sir for your valuable suggestion. The size of nanoparticles were distributed between 50 to 80 nm. I will try both oral and intravenous route sir.
Dear Ravikumar, in depend on what aim do you have in your investigation. In experimental model, from my point of veiw, you can use different ways, including intravenous, peroral, intraperitoneum. Try all possible ways and compare results..
congrats and all the best for trial . you should use Intra venous and also direct into portal vein for experimental and compare the results
Thank you so much sir.
I will add peroral, intraperitoneum and portal vein route to my study. It will sure help me for my further investigations.
On the basis of our experience, intraveinous injection of 50-80 nm NP is fine in mice and rats, to reach liver relatively rapidly. On the other hand, chronic exposures by drink lead also to NP in the liver. Intraperitioneal may lead, but it is more difficult to design if translation into patients is planned. PM
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