I am interested in stabilizing a protein that has a low affinity tetramer by fusing the monomers to a protein domain with a high propensity for tetramerization. The protein of interest is a dimer of heterodimers, so a tetramerization domain of similar make would be ideal to form the correct assembly of the protein of interest.  Can anyone recommend a small domain that forms a high affinity tetramer of this nature (dimer of heterodimers) and is amenable to being fused to a larger domain?

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