Good Day! According to Kreuziger et. al (2018), RBC transfusion is not associated with a risk for arterial or venous thrombosis.

The study was conducted to assess the risk of thrombosis in all hospitalized patients in patients admitted to 12 hospitals located across the United States. The researchers used the REDS-III database, which contains detailed information about comorbidities, medications, and transfusion timing, allowing them to precisely define a thrombotic episode and its temporal relationship to RBC transfusion, as well as adjust for confounders that were not available in other datasets.

Their findings do not rule out the possibility of a patient subset in which RBC transfusion increases the risk of thrombosis, such as patients with an underlying genetic hypercoagulable risk, but they do suggest that RBC transfusion does not appear to be an important risk factor for thrombosis in the majority of patients. As a result, receiving a blood transfusion should have no bearing on decisions regarding venous thrombosis prophylaxis in hospitalized patients.

Source: Lisa Baumann Kreuziger, Gustaf Edgren, Ronald G. Hauser, Daniel Zaccaro, Joseph Kiss, Ann Butler Zimrin, Matt Westlake, Donald Brambilla, National Heart, Lung and Blood Institute Recipient Epidemiology and Donor Evaluation Study-III (REDS-III), Alan E. Mast; Red Blood Transfusion Does Not Increase Risk for Venous or Arterial Thrombosis. Blood 2018; 132 (Supplement 1): 415. doi: https://doi.org/10.1182/blood-2018-99-109844

In the presence of a pronounced deficit in the volume of circulating blood - yes!

Erytrhocytes and platelets in stored blood components release microparticles, which present procoagulant potential.

According to the findings of our study, not an impact on the maximum platelet aggregation but an exosome-induced positive effect on hemostasis may be possible.

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