Kornelius Zeth

10 Questions 9 Answers 0 Followers

Questions related from Kornelius Zeth

Which amino acids to mutate to avoid proteolysis?

We want to suppress self proteolysis of a protein. What is the strategy to modify the sequence in order to make it stable? The site is SLG - NX and SLG - AX.

26 May 2024 7,700 0 View

Which programs or servers allow the determination of hydrophobic protein patches?

Dear all - I'm trying to analyze hydrophobic patches on protein structures towards their size area. I have read previous postings and found some servers that would do such calculations. However,...

13 December 2023 7,431 0 View

Can we study biofilms of Pseudomonas in a lab with low budget regarding antibiotic activity?

Dear all - we would like to produce and study biofilms of Pseudomonas aeruginosa. We are not well equipped, only a simple microscope. I wonder if it could be possible to make estimations on the...

04 October 2023 2,610 2 View

What are the requirements to run Alphafold2 on PC or notebook?

Dear all, I want to use Alphafold to run this program on my labtop or a server which we will install rather soon. At the moment I run AF using Colab and this work well. But in the future I will...

17 November 2022 4,631 1 View

Can Asthma be treated using bacterial metabolites such as acetate?

Dear all - I'm trying to understand if it might be an idea to treat Asthma by using small molecules produced by bacterial microbiomes. I read that several small molecules such as Ac, Propionate...

19 November 2020 7,586 2 View

How can I produce an atomic displacement plot of two protein structures (e.g. +/- ligand)?

Dear all - I would like to see the atomic displacement of two protein structures e.g. one with and the other without a ligand or domain and plot this on the sequence. Could you let me know how you...

13 April 2020 6,744 0 View

How can we identify the receptor of a small molecule in bacteria?

Hi all - I was wondering how one could 'easily' identify the receptor of a small molecule in bacteria. Background: we identified a small molecule that inhibits biofilm formation in Salmonella and...

29 August 2019 8,864 2 View

Size exclusion chormatography of needle-like proteins

Are there any data/program/server available to predict/approximate the running behaviour (peak retention) of a needle like protein (7 x 2 x 2 nm) on a size exclusion column. Thanks and best...

30 January 2017 1,990 6 View

Does anyone know a reliable citation in the distribution of lipids in the inner and outer membrane of E. coli?

I would like to see a table of the lipid content of any Gram-negative bacterium.

22 September 2013 9,474 0 View

Can a peptide bind more strongly to an unfolded than the same protein in a folded state?

If there was a peptide that binds specifically to a folded protein, can it also bind to the same unfolded protein? Would it be logical to assume that a peptide can generally bind more strongly...

01 January 1970 1,034 6 View