This review on animal models of NAFLD/NASH might help you. It gives a nice overview and also the advantages and disadvantages of the models used. There are several dietary NASH models, so you can try to use those if you prefer non-GM animal models.
Dear Dafna,
Many thanks for the quick informative review.
we developed a mouse model (B6 mice) where we put them on a high-fat diet and degassed 7Up (fructose). These animals establish prediabetic traits much sooner than just high-fat alone. One issue- no fibrosis.
By the way you live in a beautiful city.
This paper will be helpful http://www.ncbi.nlm.nih.gov/pubmed/14535984
Thank you Hovsep,
It is interesting that there is a sexual dimorphism. I just found out that a low-methionine /choline deficient diet is much more milder to the mice in terms minimizing weight loss.
- Badges
- Science topic
- Similar topics
- Medicine
- Disease
- Disease Models
- Animal Models
- Rodent Models
- Mouse Models