Several publication have different values of hydroyxproline in mouse lungs with and with out being challenged with bleomycin. In my a recent study I ran, the values were similar between naïve and bleo challenged mice. In a cohort study the Mason trichrome histology showed huge differences. Ran the study according to vendor.
Thank you in Advance,
Henry
This question takes me back to my postdoctoral research years. Attached are the PubMed links to two bleomycin mouse lung publications I co-authored ("Potentiating effects of oxygen in lungs damaged by methylcyclopentadienyl manganese tricarbonyl, cadmium chloride, oleic acid, and antitumor drugs" and "Hyperoxia, but not thoracic X-irradiation, potentiates bleomycin- and cyclophosphamide-induced lung damage in mice"), Also attached is a "Bleomycin and cyclophosphamide toxicity in mice with damaged lung tissue" publication by someone I used to work with.
http://www.ncbi.nlm.nih.gov/pubmed/6189266
http://www.ncbi.nlm.nih.gov/pubmed/6179446
http://www.ncbi.nlm.nih.gov/pubmed/2473544
Hello Pertii,
I appreciate the response as well as the articles. By some chance did you ever work with George Martin at the NIH