e.g. details of in-silico model, in vitro model, in vivo model etc?
a good start would be to look at the work made at OECD, have a look at docs in the link, I guess those report will lead you to several references:
http://www.oecd.org/science/nanosafety/
What is the route of entry?
Inhalation? Ingestion? Injection? Topical?
Are these industrial particles that may come into contact with people?
Are they intended for medical applications?
Stuart Sir,
The routes are oral and inhalation.
These are NPs used in food and medicinal industries.
In vivo models are the most represetative, but due to 3Rs application, I recomend you to use in vitro models. According to your previous answer indicating that the routes are oral and respiratory, I recomend you to use intestinal model based on CaCo-2 cells cultured on transwells for absorption and toxicity. You can also co-culture them with endothelial cells and mimic the crossing towards the blood vessels. For inhalation toxicity, MucilAir model from Epitheliz Sarl (http://www.epithelix.com/content/view/6/5/) is a good alternative to in vivo testing.
You can go through one of review paper which summarizes the most modern toxicity screening models:
Small. 2013 May 27;9(9-10):1504-20. doi: 10.1002/smll.201201452. Epub 2012 Sep 28.
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