Hello, dear Mohammed Sohel Chowdhury.

using the pharmacophore model you can search and find any molecule which is similar to your model, then you can make a big database and test them and find your lead compound. 

So basically, you are asking for the application of pharmacophore in drug design and discovery. Pharmacophore helps in retrieving the compounds that are having same features like your model (vital part of a drug). Read as many articles as possible to get clear understanding.

Please go through the links attached. 

http://www.sciencedirect.com/science/article/pii/S135964461000111X

http://www.kppub.com/articles/jan2011/pharmacophore_in_drug_design.html

Dear Mohammad Sohel Chowdhury,

Indeed, pharmacophore modeling has wider applicability domain and people have exploited it for the scaffold hopping as well. You can yourself discover what else can be done by going through these links:

http://www.drugdiscoverytoday.com/view/15584/pharmacophore-modeling-and-applications-in-drug-discovery-challen

http://www2.far.fiocruz.br/farmanguinhos/images/Sheng-Yong%20Yang.pdf