I would like to know the important genes involved in adipogenesis regulatory mechanism during high fat fed condition in Wistar rats or during type-2 diabetic condition...
Type II diabetes can be associated to obesity (metabolic syndrome with insuline resistance). Adiponectin is protective against such resistance wheras adipokynes (cytokines produced by adipose tissue and probably induced by the massive presence of fatty acids that constitute an inflammatory stimulus) have an opposite effect: when such cytokines activate kinases such as JNK and IKK, they phosphorilate the substrate of insuline receptor IRS in anomalous positions and it cannot work correctly. GLUT4 transporter and STAMP2 are other two proteins that are involved in the occurrence of insuline resistance. These are just a few information, because at present not all genes and factors involved are known.
Hi
A recent publication has shown that two of the fat older people who were free of diabetes turned out to have a mutation that destroyed one copy of the ZnT8 gene.
Rare Mutation Kills Off Gene Responsible for Diabetes.
http://www.nytimes.com/2014/03/03/health/rare-gene-protects-against-type-2-diabetes-even-in-obese-
Hi,
The major players in regulation of adipogenesis are adiponectin and IL-10. The negative regulators are Resistin, Leptin, TNF-alpha, IL-6, CCL2. Commercial ELISA kits are available for these genes. Hope this is useful!!
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