Hi to All,
I am working on synergistic effect of two drugs,i want to check these drugs effect in insilico method.how can i check these effect in insilico method.
Dear Prasath,
The following recent review article entitled " Modelling of compound combination effects and applications to efficacy and toxicity: state-of-the-art, challenges and perspectives" by Krishna C. Bulusu et al. published in Drug Discovery Today Volume 21, Issue 2, February 2016, Pages 225–238 reviews the current state-of-the-art in the field of compound combination modelling, with the aim to support the development of approaches that lead to an integration of chemical with systems-level biological information for predicting the effect of chemical mixtures.
You may determine the synergistic effect of your drugs utilizing one or more of the methods described in this recent review.
To access this review article, please use the following link:
http://www.sciencedirect.com/science/article/pii/S1359644615003438
Hoping this will be helpful,
Rafik
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