General understanding is that postbiotic particularly those that are heat-treated are stable to heat and their activity remains stable during gastric journey. Wondering if this is true for all postbiotic?
Even within the same species and strain, stability in the gastric environment can vary, being either stable or unstable. To develop probiotic products, many species and strains undergo the gastric journey to identify those that are tolerant of the gastric environment. In other words, only a few probiotic strains within the same species may be suitable for further application. Moreover, the gastric tolerance of a strain can vary depending on its growth conditions.
thanks Yeong Yeol Kim . I am aligned with your comment on probiotics ability to survive gastric journey is strain/species dependent. My question is if postbiotic where a probiotic has been heat-treated (and has been shown to have efficacy in humans) would you say that its resistant/stable to the gastric acid or would that be an assumption and you would want to see data like an in-vitro simulation of gastric survival?
I'm concerned that I might misunderstand your answer. What type of heat treatment are you referring to? There are various heat treatment methods for producing probiotics, such as heat shock (temperatures higher than optimal for fermentation), spray drying (above 130°C), and others. Heat treatment can involve many different conditions.
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