This is highly dependent on the way in which these two components are isolated form each other. as you may know the break down voltage if typical air is about 3KV/mm. so your distance and voltage rating seems to be safe against any discharge. but the important factor which you may worry about the in induced electrical and magnetic field form you AC high voltage source. to decide about it some detailed information about the structure and the robustness of you DC drive against induced electrical and magnetic field is required.
This high voltage electrode is isolated by 2 mm quartz or ceramic, and have around 10 KHz frequency, but DC power has very less voltage around 5 V and 1 A current.
I will also do EMI test as recommended by Preston Guynn