Hello, could anyone tell me if immunomodulatory drugs, such as cyclosporin A and Tacrolimus, are associated with changes in histones? I know that the inhibition of calcineurin by cyclosporin A blocks the action of BRG1, the ATPase subunit of the SWI/SNF chromatin remodeling complex. However, I am looking for studies associating the use of immunomodulators with changes in histones. Does anyone have knowledge about the subject or could you give me references (I have not found many)?
Hi, Marcela.
You are exactly right. Any drugs could have some kind of inhibition or stimulation. The drugs has a very ill-defined name 'immunomdulatory'. Lots of drugs has been developed so far. Some of the drugs are found to have role(s) something else unlike the initial purposes. Cyclosporin derivatives appears to influence on the modification of post-translation in general. Among them histone methylation and acetylation may be included by the evidences reported although in its early stage (Ref). You may find something in the references.
Ref
- J Immunol March 15, 2016, 196 (6) 2431-2437; DOI: https://doi.org/10.4049/jimmunol.1502643
- Cell Cycle, 5:23, 2738-2743, DOI: 10.4161/cc.5.23.3522 http://dx.doi.org/10.4161/cc.5.23.3522
- The Journal of Biological Chemistry 281, 36828-36834. http://www.jbc.org/content/281/48/36828.full
- Histone deacetylases: complex transducers of nuclear signals. Seminars in Cell & Developmental Biology 10(2), 1999, 179-188.
Dr. Lee,
I thank you very much for your consideration. Your information was of great help to me. Although the immunomodulators target the lymphocytes, I suspect and have evidence that their topical use greatly affects the structure of chromatin in other non-immune cells.
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