Cardiotoxin from Naja mossambica mossambica is commonly injected into skeletal muscle to induce experimental muscle. It appears that this product was sold exclusively by Sigma-Aldrich. The product has unfortunately been discontinued. I would be grateful for advice on suitable alternatives to induce experimental muscle damage in rodent models. Thank you!
I study rats and mice. I use CTX to induce experimental damage to study subsequent regeneration.
Latoxan has cardiotoxin from Naja Pallida, which has been used by other investigators to induce experimental muscle damage. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252070/
Notexin (venom from the Australian tiger snake) is also another alternative
Article Properties of regenerated EDL mouse muscle following notexin injury.
Thank you, Dr. Houweling. Do you happen to know if there are any known differences in the timeline for damage and regeneration for CTX versus notexin?
This recent paper does a comparison:
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0147198
I have been advised that the following product is a good substitute:
http://www.emdmillipore.com/US/en/product/Cardiotoxin-Naja-pallida,EMD_BIO-217503#anchor_PDS
I have not yet tried it - so I would be grateful for feedback on how it works. Thank you!
Hi,
Does anyone know if the potency of Naja pallida is comparable to Naja mossambica for mice muscle injury? Can I use the same concentration I was using with mossambica?
Thanks
Wendy
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