Hi

If you are looking in general for adsorption/desorption of chemicals on zeolites and molecular sieves then you may be wanting to focus your search on various chemical engineering research groups. A few examples of drug delivery kinetics are supplied below for some ideas. Also, don't for get that their references are also fair game. Good luck.

Article Controlling drug delivery kinetics from mesoporous titania t...

Article MSNCs and MgO-MSNCs as drug delivery systems to control the ...

Article Kinetics of Protein Adsorption and Desorption on Surfaces wi...

Hi, try this reference, it may help you:

Expert Opin Drug Deliv. 2010 April ; 7(4): 429–444. doi:10.1517/17425241003602259.

First, experimental data and their careful analysis, and second, equations and functions. Moreover, it is important what you want to achieve. If you only care about the description of single kinetic curves, that is really scientifically worthless data archiving, you can use any function reflecting the shape of the curve. Most do. A good source of equations and functions is chemical kinetics, but also rheology, and that's where I would look for inspiration to correctly describe the data. All the equations and functions used to describe the sorption kinetic data with two exceptions (Lagergren's equation and SRT equation) have been used previously in chemical kinetics and rheology.

Thank you friends for your answers and references. Now, hands on the search! Hugs

Eliezer Ladeia Gomes If you have kinetic data, just present it here. Then it's easier to advise something. I also wonder what you mean by "chemical kinetics equations (1st order, 2nd order, etc)". The point of view of those involved in chemical reactions is different from that of those involved in adsorption/desorption.

Yes, Professor. Soon I'm going to upload my data. It's very good to share this kind of problem with you and other researchers. My equations were fit as 2nd order kinetics... Hugs.

Eliezer Ladeia Gomes, Well, and where is that data you want to share with others? As I understand it, you matched the kinetic data with the hyperbolic function of the form: q=qo/(1+qokt) (being a solution of the mass balance equation: dq/dt=-kq2, q(0)=qo), and it concerned not one kinetic curve, but several curves together - for different qo values. I also hope you know that the kinetic equation for a 2nd order irreversible desorption is r=kq2.

Hi,

Like other molecules, the kinetics of drugs adsorption can be presented using various existing models. These are some of the articles related to adsorption of emerging contaminants conducted by my team for your future references, if applicable.

ATENOLOL SEQUESTRATION USING ACTIVATED CARBON DERIVED FROM GASIFIED GLYRICIDIA SEPIUM, October 2020, Arabian Journal of Chemistry 13:7544–7557

DOI: 10.1016/j.arabjc.2020.08.029

Amino-functionalised silica-grafted molecularly imprinted polymers for chloramphenicol adsorption, May 2020, Journal of Environmental Chemical Engineering 8(5):103981

DOI: 10.1016/j.jece.2020.103981

Ordered mesoporous carbons originated from non-edible polyethylene glycol 400 (PEG-400) for chloramphenicol antibiotic recovery from liquid phase, January 2015, Chemical Engineering Journal 260:730-739

DOI: 10.1016/j.cej.2014.09.010

Riboflavin adsorption onto multi-modal mesoporous carbon synthesized from polyethylene glycol 400, January 2013, Chemical Engineering Journal s 215–216:297–305,

DOI: 10.1016/j.cej.2012.10.031

Regards,

Azam

Hello friends,

As promised, I uploaded my students' final course work related to adsorption / controlled delivery (ASA and paracetamol using zeolites). I'm preparing the article related to it for publication (Final TCC.pdf). There's traditional modeling based on chemical kinetics.

Unfortunately, it is in Portuguese. I can translate if you have any questions. The adsorption data for paracetamol and ASA are on page 47. The controlled release data for these drugs are on page 54. Numerical data is not available here, but I can particularly send it if someone wants to try some previous modeling. Dear Prof. Mirosław Grzesik , promise fulfilled!

Thank you Dr. Azam Taufik Mohd Din for your answer!

Hugs

Prof. Eliezer

Eliezer Ladeia Gomes, It's nice that you remembered and included both the kinetic data and the calculation results. Unfortunately, I have to worry you, but I find the results in Table 11 on page 55 for HMOR and HBEA unreliable. The reason is too little change in mass and too many points close to equilibrium in relation to the others. Graphical methods that further falsify the results must not be used for such data. In the case of HBEA, nonlinear regression would also not help much. I advise against publishing such calculation results. Regards,

Thank you very much, Prof. Miroslaw Grzesik, for your observations. I'll review these data and study how to correct the analysis. My intention is to treat these data with the necessary correction and rigidity for a publication that clarifies this type of adsorption process and helps other researchers in the area. Prof. Bestani Benaouda has sent to me a good paper to help with this analysis and I'll think about how to present a reliable result. May I ask you privately about my doubts? Hugs!